How Do I resolve issues with DMRcate, bumphunter & CURL_OPENSSL_3? - r

Question

I am trying to load a library - specifically DMRcate and there seem to be several issues that pop up and I am unsure as to how to resolve these issues.
First I tried: to simply load the library for DMRcate
library(DMRcate)
however, I got the following error message:
Loading required package: minfi
Loading required package: bumphunter
Error: package or namespace load failed for ‘bumphunter’ in dyn.load(file, DLLpath = DLLpath, ...):
unable to load shared object 'filepath/Rsamtools.so':
filepath/libcurl.so.4: version `CURL_OPENSSL_3' not found (required by filepath/Rsamtools.so)
Error: package ‘bumphunter’ could not be loaded
Traceback:
1. library(DMRcate)
2. .getRequiredPackages2(pkgInfo, quietly = quietly)
3. library(pkg, character.only = TRUE, logical.return = TRUE, lib.loc = lib.loc,
. quietly = quietly)
4. .getRequiredPackages2(pkgInfo, quietly = quietly)
5. stop(gettextf("package %s could not be loaded", sQuote(pkg)),
. call. = FALSE, domain = NA)
then I simply tried to get around by adding the bumphunter library to the beginning section of code:
library(DMRcate)
library(bumphunter)
however this error message pops up:
Loading required package: minfi
Loading required package: bumphunter
Error: package or namespace load failed for ‘bumphunter’ in dyn.load(file, DLLpath = DLLpath, ...):
unable to load shared object 'filepath/Rsamtools.so':
filepath/libcurl.so.4: version `CURL_OPENSSL_3' not found (required by filepath/Rsamtools.so)
Error: package ‘bumphunter’ could not be loaded
Traceback:
1. library(DMRcate)
2. .getRequiredPackages2(pkgInfo, quietly = quietly)
3. library(pkg, character.only = TRUE, logical.return = TRUE, lib.loc = lib.loc,
. quietly = quietly)
4. .getRequiredPackages2(pkgInfo, quietly = quietly)
5. stop(gettextf("package %s could not be loaded", sQuote(pkg)),
. call. = FALSE, domain = NA)
I am not sure what I am doing wrong? I am using a cluster and I cannot use sudo or apt-get as this isn't allowed. I am using a Mac Air M2. Could anyone help me to know what is wrong with the code I have written?
I then tried to install the packages itself in Jupyter notebooks:
if (!require("BiocManager"))
install.packages("BiocManager")
BiocManager::install("bumphunter")
But then the error was odd
Error: Bioconductor version cannot be validated; no internet connection?
Traceback:
1. BiocManager::install("bumphunter")
2. .version_validate(version)
3. ifelse(.is_CRAN_check(), .message(txt), .stop(txt))
4. .stop(txt)
5. stop(.msg(...), call. = call.)
I am connected to the internet, and the HPC and on site. What am I doing wrong?