Minimizing the size of docker image R shiny app - r

Question

Good afternoon to everybody.
I deployed a shiny app in Docker.
I need Bioconductor packages/ I find the way and the app working properly.
But now I've got shown that is very big size the app.
probably this is due to 2 layers ( 1 of the app and 1 of the Bioconductor packages.)
I have read also that I must remove the second docker layer and try to install Bioconductor on the rocker/shiny image. But I do not know how to realize that information. I attach the dockerfile.
Does anybody have idea please to make lighter the app in docker?
# Base image https://hub.docker.com/u/rocker/
FROM rocker/shiny:latest
# system libraries of general use
## install debian packages
RUN apt-get update -qq && \
apt-get upgrade -y && \
apt-get -y --no-install-recommends install \
libxml2-dev \
libcairo2-dev \
libsqlite3-dev \
libmariadbd-dev \
libpq-dev \
libssh2-1-dev \
unixodbc-dev \
libcurl4-openssl-dev \
libssl-dev \
coinor-libcbc-dev coinor-libclp-dev libglpk-dev && \
apt-get clean
# Docker inheritance
FROM bioconductor/bioconductor_docker:RELEASE_3_12
RUN apt-get update
RUN R -e 'BiocManager::install(ask = F)' && R -e 'BiocManager::install(c("rtracklayer", \
"GenomicAlignments", "Biostrings", "SummarizedExperiment", "Rsamtools", ask = F))'
# copy necessary files
## app folder
COPY ./folder ./app
# install renv & restore packages
RUN Rscript -e 'install.packages("renv")'
RUN Rscript -e 'install.packages("devtools")'
RUN Rscript -e 'install.packages("shiny")'
RUN Rscript -e 'install.packages("shinyBS")'
RUN Rscript -e 'install.packages("ggvis")'
RUN Rscript -e 'install.packages("shinycssloaders")'
RUN Rscript -e 'install.packages("shinyWidgets")'
RUN Rscript -e 'install.packages("plotly")'
RUN Rscript -e 'install.packages("RSQLite")'
RUN Rscript -e 'install.packages("knitr")'
RUN Rscript -e 'install.packages("knitcitations")'
RUN Rscript -e 'install.packages("Matrix")'
RUN Rscript -e 'install.packages("plotly")'
RUN Rscript -e 'install.packages("igraph")'
RUN Rscript -e 'install.packages("ggthemes")'
RUN Rscript -e 'install.packages("evaluate")'
RUN Rscript -e 'install.packages("psych")'
RUN Rscript -e 'install.packages("kableExtra")'
RUN Rscript -e 'install.packages("ggjoy")'
RUN Rscript -e 'install.packages("gtools")'
RUN Rscript -e 'install.packages("gridExtra")'
RUN Rscript -e 'install.packages("ggrepel")'
RUN Rscript -e 'install.packages("data.table")'
RUN Rscript -e 'install.packages("stringr")'
RUN Rscript -e 'install.packages("rmarkdown")'
RUN Rscript -e 'install.packages("shinyjqui")'
RUN Rscript -e 'install.packages("V8")'
RUN Rscript -e 'devtools::install_github("ThomasSiegmund/D3TableFilter")'
RUN Rscript -e 'devtools::install_github("leonawicz/apputils")'
RUN Rscript -e 'devtools::install_github("dirkschumacher/ompr")'
RUN Rscript -e 'devtools::install_github("dirkschumacher/ompr.roi")'
RUN Rscript -e 'install.packages("shinydashboard")'
RUN Rscript -e 'install.packages("dplyr")'
RUN Rscript -e 'install.packages("shinyjs")'
RUN Rscript -e 'install.packages("DT")'
RUN Rscript -e 'install.packages("rhandsontable")'
RUN Rscript -e 'renv::consent(provided = TRUE)'
RUN Rscript -e 'renv::restore()'
# expose port
EXPOSE 8080
# run app on container start
CMD ["R", "-e", "shiny::runApp('/app', host = '0.0.0.0', port = 8080)"]