Chi Square Test of Independence of Whole Dataset - r

Question

I have a 3185x90 dataset of binary values and want to do a chi-squared test of independence, comparing all column variables against each other.
I've been tried using different variations of code from google searches with chisq.test() and some for loops, but none of them have worked so far.
How do I do this?
This is the frame I've tinkered with. My dataset is oak.
chi_trial <- data.frame(a = c(0,1), b = c(0,1))
for(row in 1:nrow(oak)){
print(row)
print(chisq.test(c(oak[row,1],d[row,2])))
}
I also tried this:
apply(d, 1, chisq.test)
which gives me the error: Error in FUN(newX[, i], ...) :
all entries of 'x' must be nonnegative and finite
dput(oak[1:2],)
structure(list(post_flu = structure(c(1, 1, 1, 1, 1, 0, 0, 0,
0, 0, 1, 1, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,
1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0,
0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 0,
0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 0, 0,
0, 0, 1, 1, 1, 1, 1, 0, 0, 0, 0, 0, 1, 1, 1, 1, 1, 0, 0, 0, 0,
0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 1, 1,
1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 0, 0, 0, 0, 1,
1, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
0, 0, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0,
label = "Receipt of Flu Vaccine - Encounter Survey", format.stata = "%10.0g")), row.names = c(NA,
-3185L), class = c("tbl_df", "tbl", "data.frame"), label = "Main Oakland Clinic Analysis Dataset")
I added a sample of my data with the final lines of the output. The portion of the dataset is small, but it all looks like this.

Answer 1

You could use something like the code below, which is similar to R's cor function. I don't have your data, so I'm simulating some. Note that I get one significant p-value, using the traditional cut-off of 0.05.
set.seed(3)
nr=3185; nc=3
oak <- as.data.frame(matrix(sample(0:1, size=nr*nc, replace=TRUE), ncol=nc))
oak
mult.chi <- function(data){
nc <- ncol(data)
res <- matrix(0, nrow=nc, ncol=nc) # or NA
for(i in 1:(nc-1))
for(j in (i+1):nc)
res[i,j] <- suppressWarnings(chisq.test(oak[,i], oak[,j])$p.value)
rownames(res) <- colnames(data)
colnames(res) <- colnames(data)
res
}
mult.chi(oak)
# V1 V2 V3
# V1 0 0.7847063 0.32012466
# V2 0 0.0000000 0.01410326
# V3 0 0.0000000 0.00000000
So consider applying a multiple testing adjustment as mentioned in the comments.

Answer 2

Here is a solution with combn to get all combinations of column numbers 2 by 2. Tested with the data in #Edward's answer.
chisq2cols <- function(X){
y <- matrix(0, ncol(X), ncol(X))
cmb <- combn(ncol(X), 2)
y[upper.tri(y)] <- apply(cmb, 2, function(k){
tbl <- table(X[k])
chisq.test(tbl)$p.value
})
y
}
chisq2cols(oak)
# [,1] [,2] [,3]
#[1,] 0 0.7847063 0.32012466
#[2,] 0 0.0000000 0.01410326
#[3,] 0 0.0000000 0.00000000