Time-dependent events in ODE - julia

Question

I recently started with Julia and wanted to implement one of my usual problems - implement time-depended events.
For now I have:
# Packages
using Plots
using DifferentialEquations
# Parameters
k21 = 0.14*24
k12 = 0.06*24
ke = 1.14*24
α = 0.5
β = 0.05
η = 0.477
μ = 0.218
k1 = 0.5
V1 = 6
# Time
maxtime = 10
tspan = (0.0, maxtime)
# Dose
stim = 100
# Initial conditions
x0 = [0 0 2e11 8e11]
# Model equations
function system(dy, y, p, t)
dy[1] = k21*y[2] - (k12 + ke)*y[1]
dy[2] = k12*y[1] - k21*y[2]
dy[3] = (α - μ - η)*y[3] + β*y[4] - k1/V1*y[1]*y[3]
dy[4] = μ*y[3] - β*y[4]
end
# Events
eventtimes = [2, 5]
function condition(y, t, integrator)
t - eventtimes
end
function affect!(integrator)
x0[1] = stim
end
cb = ContinuousCallback(condition, affect!)
# Solve
prob = ODEProblem(system, x0, tspan)
sol = solve(prob, Rodas4(), callback = cb)
# Plotting
plot(sol, layout = (2, 2))
But the output that is give is not correct. More specifically, the events are not taken into account and the initial condition doesn't seems to be 0 for y1 but stim.
Any help would be greatly appreciated.

Answer 1

t - eventtimes doesn't work because one's a scalar and the other is a vector. But for this case, it's much easier to just use a DiscreteCallback. When you make it a DiscreteCallback you should pre-set the stop times so that to it hits 2 and 5 for the callback. Here's an example:
# Packages
using Plots
using DifferentialEquations
# Parameters
k21 = 0.14*24
k12 = 0.06*24
ke = 1.14*24
α = 0.5
β = 0.05
η = 0.477
μ = 0.218
k1 = 0.5
V1 = 6
# Time
maxtime = 10
tspan = (0.0, maxtime)
# Dose
stim = 100
# Initial conditions
x0 = [0 0 2e11 8e11]
# Model equations
function system(dy, y, p, t)
dy[1] = k21*y[2] - (k12 + ke)*y[1]
dy[2] = k12*y[1] - k21*y[2]
dy[3] = (α - μ - η)*y[3] + β*y[4] - k1/V1*y[1]*y[3]
dy[4] = μ*y[3] - β*y[4]
end
# Events
eventtimes = [2.0, 5.0]
function condition(y, t, integrator)
t ∈ eventtimes
end
function affect!(integrator)
integrator.u[1] = stim
end
cb = DiscreteCallback(condition, affect!)
# Solve
prob = ODEProblem(system, x0, tspan)
sol = solve(prob, Rodas4(), callback = cb, tstops = eventtimes)
# Plotting
plot(sol, layout = (2, 2))
This avoids rootfinding altogether so it should be a much nicer solution that hacking time choices into a rootfinding system.
Either way, notice that the affect was changed to
function affect!(integrator)
integrator.u[1] = stim
end
It needs to be modifying the current u value otherwise it won't do anything.