:not fire any event in updatepanel - asp.net

Question

i have a website with .Net2 . I Changed it built target to .Net4.5 and changed it pool to .net 4 from IIS. but any event in updatepanel not firing(such as butun_click or dropdown_Changed and ...) all of them work correctly on .net 2.
any idea?
Edit:
i delete:
<section name="scriptResourceHandler" type="System.Web.Configuration.ScriptingScriptResourceHandlerSection, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35" requirePermission="false" allowDefinition="MachineToApplication"/>
<section name="jsonSerialization" type="System.Web.Configuration.ScriptingJsonSerializationSection, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35" requirePermission="false" allowDefinition="Everywhere"/>
<section name="profileService" type="System.Web.Configuration.ScriptingProfileServiceSection, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35" requirePermission="false" allowDefinition="MachineToApplication"/>
<section name="authenticationService" type="System.Web.Configuration.ScriptingAuthenticationServiceSection, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35" requirePermission="false" allowDefinition="MachineToApplication"/>
<section name="roleService" type="System.Web.Configuration.ScriptingRoleServiceSection, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35" requirePermission="false" allowDefinition="MachineToApplication"/>
from web.config becuase duplicated error.

Answer 1

finally i found the solution.
the problem was with this line:
Sys.WebForms.PageRequestManager.getInstance().add_initializeRequest(InitializeRequestHandler);
function InitializeRequestHandler(sender, eventArgs) {
if (sender._postBackSettings.panelID.indexOf('folCountTimer') != -1) {
return;
}
$("#updateProgresJQuery").slideDown(300);
}
i delete it and every thing work correctly.